Pure Ephedrine HCL

Pure Ephedrine (Eph / Ephs / Ephy) is a sympathomimetic medication, which is commonly used as a stimulant, appetite suppressant, concentration aid, decongestant and fat burner. Pure Ephedrine is similar in chemical structure to the synthetic derivatives amphetamine and methamphetamine.

Ephedrine HCl as it stands is commonly marketed in its HydroChLoride (HCL / HCl) and Sulfate forms. In Traditional Chinese Medicines and Remedies, the herb Má Huáng or Ma Huang (Ephedra Sinica) contains both Ephedrine and Pseudoephedrine as its principal active constituents. It's commonly just referred to as Ephedra. This chemical make-up means Ephedra works in slightly different ways and has different actions and effects to its sythetic counter-part Ephedrine HCl. The same is true of other herbal products containing extracts from Ephedra species. Ephedrine was first derived from the from Ephedra Vulgaris plant in 1885.

Pure Ephedrine weakly increases noradrenergic receptor activity directly by activating both α-receptors (Alpha) and β-receptors (Beta). Beta receptors are also the same receptors that Clenbuterol works on. However the bulk Ephedrines effects come from the synaptic neuron being unable to tell the between real both adrenaline and / or noradrenaline from Pure Ephedrine HCL. When ephedrine is mixed with noradrenaline, it is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into nerve cells. So when you need the adrenaline, its released along with Ephedrine to start its effects.

As an alkaloid, having just a small amount of ephedrine inside a cell increases the overall pH of the cell. This has the effect of increasing likelihood that the ephedrine affected cells will be released during any subsequent action which requires an adrenaline boost. This roughly means the more active you are, the more cells are released, and the more ephedrine and adrenaline is delivered into your system for a stronger effect.

Its action as an agonist at most major noradrenaline receptors and its ability to increase the release of both Dopamine and to a lesser extent, Serotonin by the same mechanism as explained above for norepinephrine. Because of ephedrine's ability to potentiate Dopamine neurotransmission it is thought to have addictive properties by some researchers.

While Ephedrine's role in the serotonin system is less understood there is preliminary documentation of clinically significant agonism at excitory serotonin receptors, perhaps as a downstream response to the large release of norepinephrine in the Nucleus Accumbens (commonly referred to as the "Pleasure Center" of the brain). In mice, stereotypical behaviour was both easily induced by administration of ephedrine and its primary alkaloids and reversed when serotonin antagonists were administered.